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KMID : 0357920000340070488
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Korean Journal of Pathology
2000 Volume.34 No. 7 p.488 ~ p.493
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Clinicopathologic Characteristics of Replication Error-Positive Gastric Adenocarcinoma in Korean
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Lee Jae-Hyuk
Kim Mi-Hwa
Lee Wan-Sik
Kim Young-Jin
Jee Mi-Sun
Lee Kwang-Min
Juhng Sang-Woo
Choi Chan
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Abstract
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The purpose of this study is to obtain the clinicopathological characteristics of replication error-positive (RER+) gastric adenocarcinoma in Korean, and to identify the significance of RER+ in adenoma stage of gastric carcinogenesis. Microsatellite instability was examined at D2S71, D2S119, D3S1067, D6S87, D11S905, DM, AR, VWF, HPRT, and BAT-26 loci. Frameshift mutation of BAX gene was analyzed in RER+ tumors. Normal and tumor DNA of 76 cases of gastric carcinoma and 25 cases of adenoma were examined. RER+ was found in 8 of 76 cases (10.5%), and it was more frequently found in adenocarcinoma of female (17.7%) than those of male (4.8%). The frequency of RER+ was not different between the histologic types, age of the patient, anatomical location of the carcinoma, and the stage. The RER+ found in adenoma suggests that RER+ contributes to the malignant transformation early in the adenoma stage of the gastric carcinogenesis. None of the RER+ tumors revealed frameshift mutation of the BAX gene.
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KEYWORD
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Gastric adenocarcinoma, Microsatellite instability, Replication error phenotype, BAX, Clinicopathologic characteristics
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